Journal article
Uteroplacental insufficiency in rats induces renal apoptosis and delays nephrogenesis completion
JSM Cuffe, JF Briffa, S Rosser, AL Siebel, T Romano, DH Hryciw, ME Wlodek, KM Moritz
Acta Physiologica | WILEY | Published : 2018
DOI: 10.1111/apha.12982
Abstract
Aim: Uteroplacental insufficiency in rats reduces nephron endowment, leptin concentrations and programmes cardiorenal disease in offspring. Cross-fostering growth-restricted (Restricted) offspring onto a mother with normal lactation restores leptin concentrations and nephron endowment. This study aimed to determine whether the reduced nephron endowment in Restricted offspring is due to delayed glomerular formation and dysregulation of renal genes regulating branching morphogenesis, apoptosis or leptin signalling. Furthermore, we aimed to investigate whether cross-fostering Restricted offspring onto Control mothers could improve glomerular maturation and restore renal gene abundance. Methods:..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council (NHMRC) of Australia (M.E.W. 208948; M.E.W. and K.M. 400003), an Early Career Researcher (ECR) grant from the University of Melbourne (D.H.H.) and a La Trobe University Faculty of Health Sciences Research Grant Award (T.R.). J.S.M.C. holds a Griffith University Postdoctoral Fellowship. J.F.B. holds an Elizabeth and Vernon Puzey Postdoctoral Fellowship at the University of Melbourne. K.M. was funded by a NHMRC Senior Research Fellowship. A.L.S. was funded by a NHMRC Early Career Fellowship.